CAS NO.: 5949-44-0
Assay: 98% min.
Molecular Formula: C30H48O3
Molecular weight: 456.70
Character: White Powedr
What Is Testosterone Undecanoate?
Testosterone undecandoate might be prescribed for the treatment of
hypogonadism in men, but more recently, the androgen has been used
as a male contraceptive. Since the 1980s, researchers have been
testing testosterone variations in an attempt to develop one. While
this testosterone ester produces effective results in Asian men,
the hormone requires the addition of other hormones to produce
equally successful outcomes for men in other countries.
This ester of testosterone suppresses follicle stimulating hormone
(FSH) and luteinizing hormone (LH), interfering with the signals
required by the testes to produce sperm and resulting in lowered
sperm counts. Men usually do not experience the full effects of
treatment, however, until after the first two or three months of
receiving the drug. Sperm counts then remain low for the duration
of treatment. Counts generally return to normal anywhere from two
to six months after cessation of treatment.
Chinese researchers first combined 200 milligrams (mg) of
testosterone undecandoate with tea tree oil and administered the
formula by intramuscular injection. Men received periodic
injections over the course of 30 months. During the first trials,
80% to 90% of the men involved in the study developed sperm counts
of less than one million sperm per milliliter (ml) of ejaculate.
Normal sperm counts average around 20 million sperm per ml. After
three months of treatment, the male contraceptive was 90% to 100%
Testosterone Undecanoate or Testosterone Undecylate is an ester of
Testosterone. Clinically, this hormone is used in androgen
replacement therapy primarily for the treatment of male
hypogonadism, and is currently under research for use as a male
contraceptive. It is sold and distributed under the brand names
Andriol, Undestor, Nebido, Pantestone, Restandol, Cernos Depot,
Nebido-R and Reandron 1000. It aromatizes only minimally,which
means little or no increased body fat. This makes it a welcome
alternative for those who have problems with common Testosterone
compounds. Testosterone Undecanoate is also suitable for
pre-competition workouts. An additional advantage of Testosterone
Undecanoate is non-aromatizing quality consists of the fact that
the body's own hormone production is only affected after a
long-term administration of very high dosages. Testosterone
Undecanoate has only a low inhibitive effect on the hypothalamus so
that the release of LHRH (luteinizing hormone releasing hormone) is
rarely influenced. This is very important since LHRH stimulates the
hypophysis to release gonadotropine which causes the Ledig's cells
in the testes to produce Testosterone. Since Testosterone
Undecanoate is quickly eliminated by the body it should also be
considered for use before competitions requiring doping tests.
Testosterone Undecanoate/Test unde Cas5949-44-0 powders
administered orally generally enter the blood stream through the
liver. When a steroid compound is given this way without some form
of structural protection, it will be quickly broken down during the
This process leaves very little steroid intact, basically
deactivating the drug. Adding a methyl group (c-17 AA) to the
structure is one way to protect it from this process, however
stress is also placed on the liver as a result.
In some instances this stress can lead to actual damage to liver
tissues, so the designers of this steroid sought another way to
protect the testosterone molecule. With Testosterone
Undecanoate/Test unde, this was accomplished by making a form of
testosterone that would be absorbed through the lymphatic system.
This is due to its high fat solubility brought about by the ester,
and its suspension in oil.
Having the compound absorbed this way was thought to be very
advantageous, as it allows the steroid to bypass the destructive
first-pass through liver. This should permit the compound to enter
the blood stream intact, without the need for a harsh chemical
alteration. The ester breaks off once it is in circulation of
course, yielding free active Pharmacokinetics of Oral Testosterone.
In design this steroid appears to be undecanoate that of a
completely liver safe and orally active form of testosterone.
White or almost white crystalline powder
Loss on drying
The aboye product conforms analysis standard
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